Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines
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منابع مشابه
6-diazo-5-oxo-l-norleucine Inhibition of Escherichia Coli.
Coggin, J. H., Jr. (The University of Chicago, Chicago, Ill.), and W. R. Martin. 6-Diazo-5-oxo-l-norleucine inhibition of Escherichia coli. J. Bacteriol. 89:1348-1353. 1965.-The glutamine analogue 6-diazo-5-oxo-l-norleucine (DON) induced filaments and spheroplasts in Escherichia coli during the transition of sensitive populations to a state of resistance. Resistance developed at a frequency sug...
متن کاملEnhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Mouse P388 and L1210 leukemia cells grown in vitro were found to be 4 to 10 times more sensitive to 6-diazo-5-oxo-L-norleucine and 3 to 5 times more sensitive to Acivicin than were 3T3 and C57BL x DBA/2 F1 embryonic fibroblasts. The combined actions of succinylated Acinetobacter glutaminase-asparaginase and 6-diazo-5-oxo-L-norleucine or Acivicin produced synergistic inhibition of nucleic acid s...
متن کاملEnhancement of Antitumor Activity of Glutamine Antagonists 6-Diazo-5- oxo-L-norleucine and Acivicin in Cell Culture by Glutaminase- Asparaginase1
Mouse P388 and L1210 leukemia cells grown in vitro were found to be 4 to 10 times more sensitive to 6-diazo-5-oxo-Lnorleucine and 3 to 5 times more sensitive to Acivicin than were 3T3 and C57BL x DBA/2 F, embryonic fibroblasts. The combined actions of succinylated Acinetobacter glutaminaseasparaginase and 6-diazo-5-oxo-L-norleucine or Acivicin pro duced synergistic inhibition of nucleic acid sy...
متن کاملEffects of 6-diazo-5-oxo-L-norleucine on the incorporation of precursors into nucleic acids.
The tumor growth-inhibitor 6-diazo-5-oxo-L-norleucine (DOX) was shown to inhibit, from 90 to 98 per cent, the incorporation of formate-C14 into the purine bases of the nucleic acids from Sarcoma 180 tissue, small intestine, and liver, when given at the same time as the precursor formate. The inhibition was less, but still substantial, when the DOX was given in small multiple doses instead of a ...
متن کاملEvaluating the Analgesic Effect of the GLS Inhibitor 6-Diazo-5-Oxo-L-Norleucine in Vivo
Submit Manuscript | http://medcraveonline.com Abbreviations: AIA: Adjuvant-Induced Arthritis ; AST: Aspartate Amino Transferase; BSA: Bovine Serum Albumin; DON: 6-Diazo5-Oxo-L-Norleucine; DRG: Dorsal Root Ganglia; GLU: Glutamate; GLS: Glutaminase; IR: Immunoreactivity; MRNA: Messenger RNA; NSAID: Non-Steroidal Anti-Inflammatory Drug; PBS: Phosphate Buffered Saline; PBST: Phosphate Buffered Sali...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1987
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1987.133